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MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS
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DeCS
Descriptor
Inglés
:
Multidrug Resistance-Associated Proteins
Descriptor
Español
:
Proteínas Asociadas a Resistencia a Múltiples Medicamentos
Descriptor
Portugués
:
Proteínas Associadas à Resistência a Múltiplos Medicamentos
Sinónimos
Inglés
:
Multidrug Resistance-Associated Protein
Categoría:
D12.776.157.530.100.304
D12.776.157.530.450.074.500.500.500
D12.776.543.585.100.304
D12.776.543.585.450.074.500.500.500
Definición
Inglés
:
A sequence-related subfamily of
ATP-BINDING CASSETTE TRANSPORTERS
that actively transport organic
substrates
. Although considered
organic anion transporters
, a subset of
proteins
in this
family
have also been shown to convey
drug resistance
to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of
ANTINEOPLASTIC AGENTS
. Overexpression of
proteins
in this class by
NEOPLASMS
is considered a possible mechanism in the development of
multidrug resistance
(
DRUG RESISTANCE
, MULTIPLE). Although
similar
in function to
P-GLYCOPROTEINS
, the
proteins
in this class share little
sequence homology
to the
p-glycoprotein
family
of
proteins.
Relacionados
Inglés
:
Drug Resistance, Multiple
P-Glycoproteins
Nota Histórica
Inglés
:
2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
36147
Identificador Único:
D027425
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS